Nigral neurons are likely to die of a mechanism other than classical apoptosis in Parkinson's disease
Identifieur interne : 001D60 ( Main/Exploration ); précédent : 001D59; suivant : 001D61Nigral neurons are likely to die of a mechanism other than classical apoptosis in Parkinson's disease
Auteurs : M. B. Graeber [Allemagne] ; E. Grasbon-Frodl [Allemagne] ; P. Abell-Aleff [États-Unis] ; S. Kösel [Allemagne]Source :
- Parkinsonism and Related Disorders [ 1353-8020 ] ; 1999.
English descriptors
- KwdEn :
Abstract
The finding of apoptosis in Parkinson's disease (PD) represents a contentious issue. In fact, there is increasing evidence that an alternative mechanism of cell death is at work in the parkinsonian substantia nigra, which we tentatively term aposklesis. Unlike apoptosis, aposklesis (“withering”) lacks the morphological signs of apoptosis and takes a slow course which is in agreement with the predicted rate of dopaminergic cell death in PD. Cells undergoing aposklesis may stain positive in the TUNEL reaction and show a reticular nuclear labeling but lack any significant chromatin condensation and the formation of apoptotic bodies. Not only neurons but also glial cells appear to undergo this form of cell death, which represents a relatively common finding in degenerative diseases of the CNS.
Url:
DOI: 10.1016/S1353-8020(99)00036-X
Affiliations:
- Allemagne, États-Unis
- Bavière, District de Haute-Bavière, Minnesota
- Munich
- Université Louis-et-Maximilien de Munich
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Nigral neurons are likely to die of a mechanism other than classical apoptosis in Parkinson's disease</title><author><name sortKey="Graeber, M B" sort="Graeber, M B" uniqKey="Graeber M" first="M. B." last="Graeber">M. B. Graeber</name></author><author><name sortKey="Grasbon Frodl, E" sort="Grasbon Frodl, E" uniqKey="Grasbon Frodl E" first="E." last="Grasbon-Frodl">E. Grasbon-Frodl</name></author><author><name sortKey="Abell Aleff, P" sort="Abell Aleff, P" uniqKey="Abell Aleff P" first="P." last="Abell-Aleff">P. Abell-Aleff</name></author><author><name sortKey="Kosel, S" sort="Kosel, S" uniqKey="Kosel S" first="S." last="Kösel">S. Kösel</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:993B2712C7D5551D567EF0BC4F3020A9B149CAB0</idno><date when="1999" year="1999">1999</date><idno type="doi">10.1016/S1353-8020(99)00036-X</idno><idno type="url">https://api.istex.fr/document/993B2712C7D5551D567EF0BC4F3020A9B149CAB0/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002477</idno><idno type="wicri:Area/Main/Curation">002148</idno><idno type="wicri:Area/Main/Exploration">001D60</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Nigral neurons are likely to die of a mechanism other than classical apoptosis in Parkinson's disease</title><author><name sortKey="Graeber, M B" sort="Graeber, M B" uniqKey="Graeber M" first="M. B." last="Graeber">M. B. Graeber</name><affiliation wicri:level="1"><country wicri:rule="url">Allemagne</country></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Molecular Neuropathology Laboratory, Department of Neuromorphology, Max-Planck-Institute of Neurobiology, D-82152 Martinsried</wicri:regionArea><wicri:noRegion>82152 Martinsried</wicri:noRegion><wicri:noRegion>D-82152 Martinsried</wicri:noRegion></affiliation></author><author><name sortKey="Grasbon Frodl, E" sort="Grasbon Frodl, E" uniqKey="Grasbon Frodl E" first="E." last="Grasbon-Frodl">E. Grasbon-Frodl</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Molecular Neuropathology Laboratory, Institute of Neuropathology, Ludwig-Maximilians-University, D-80337 Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Abell Aleff, P" sort="Abell Aleff, P" uniqKey="Abell Aleff P" first="P." last="Abell-Aleff">P. Abell-Aleff</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Electron Microscopy Core Facility, Mayo Clinic, 200 1st Street SW, Rochester, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Kosel, S" sort="Kosel, S" uniqKey="Kosel S" first="S." last="Kösel">S. Kösel</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Molecular Neuropathology Laboratory, Institute of Neuropathology, Ludwig-Maximilians-University, D-80337 Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Parkinsonism and Related Disorders</title><title level="j" type="abbrev">PRD</title><idno type="ISSN">1353-8020</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1999">1999</date><biblScope unit="volume">5</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="187">187</biblScope><biblScope unit="page" to="192">192</biblScope></imprint><idno type="ISSN">1353-8020</idno></series><idno type="istex">993B2712C7D5551D567EF0BC4F3020A9B149CAB0</idno><idno type="DOI">10.1016/S1353-8020(99)00036-X</idno><idno type="PII">S1353-8020(99)00036-X</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1353-8020</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aposklesis</term><term>Cell death</term><term>Mitochondria</term><term>Neurodegeneration</term><term>Sequencing</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The finding of apoptosis in Parkinson's disease (PD) represents a contentious issue. In fact, there is increasing evidence that an alternative mechanism of cell death is at work in the parkinsonian substantia nigra, which we tentatively term aposklesis. Unlike apoptosis, aposklesis (“withering”) lacks the morphological signs of apoptosis and takes a slow course which is in agreement with the predicted rate of dopaminergic cell death in PD. Cells undergoing aposklesis may stain positive in the TUNEL reaction and show a reticular nuclear labeling but lack any significant chromatin condensation and the formation of apoptotic bodies. Not only neurons but also glial cells appear to undergo this form of cell death, which represents a relatively common finding in degenerative diseases of the CNS.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>États-Unis</li></country><region><li>Bavière</li><li>District de Haute-Bavière</li><li>Minnesota</li></region><settlement><li>Munich</li></settlement><orgName><li>Université Louis-et-Maximilien de Munich</li></orgName></list><tree><country name="Allemagne"><noRegion><name sortKey="Graeber, M B" sort="Graeber, M B" uniqKey="Graeber M" first="M. B." last="Graeber">M. B. Graeber</name></noRegion><name sortKey="Graeber, M B" sort="Graeber, M B" uniqKey="Graeber M" first="M. B." last="Graeber">M. B. Graeber</name><name sortKey="Grasbon Frodl, E" sort="Grasbon Frodl, E" uniqKey="Grasbon Frodl E" first="E." last="Grasbon-Frodl">E. Grasbon-Frodl</name><name sortKey="Kosel, S" sort="Kosel, S" uniqKey="Kosel S" first="S." last="Kösel">S. Kösel</name></country><country name="États-Unis"><region name="Minnesota"><name sortKey="Abell Aleff, P" sort="Abell Aleff, P" uniqKey="Abell Aleff P" first="P." last="Abell-Aleff">P. Abell-Aleff</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001D60 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001D60 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:993B2712C7D5551D567EF0BC4F3020A9B149CAB0
|texte= Nigral neurons are likely to die of a mechanism other than classical apoptosis in Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |